What Is Xeomin? How It Compares to Botox and Dysport

What Is Xeomin?

Xeomin (incobotulinumtoxinA) is an FDA-approved botulinum toxin type A—the same class of neuromodulator as Botox (onabotulinumtoxinA) and Dysport (abobotulinumtoxinA). It's used to temporarily relax muscles that cause dynamic wrinkles.

How Is Xeomin Different from Botox?

The key distinguishing feature of Xeomin is that it is "naked"—it contains only the active neurotoxin, without the complexing accessory proteins found in Botox and Dysport. These accessory proteins are not harmful, but some research suggests that the body may develop antibodies to them over time, potentially leading to reduced efficacy in long-term Botox users.

Xeomin's "naked" formulation may reduce this risk, making it a compelling option for patients who have been using Botox for many years and notice diminishing returns.

Xeomin vs. Botox vs. Dysport: At a Glance

Who Is Xeomin Good For?

• Long-term Botox users experiencing reduced efficacy
• Patients interested in a "purer" formulation
• Anyone seeking an effective alternative neuromodulator

Is One Better Than the Other?

In clinical practice, all three neuromodulators produce excellent results when administered by a skilled provider. The "best" option depends on your treatment history, goals, and provider preference.

Skin Clique providers are experienced with all major neuromodulators and will recommend the one most appropriate for your individual situation.